[PP.07.22] BIOMARKERS OF KIDNEY INJURY IN GENDER SUBGROUPS OF HYPERTENSIVE PATIENTS. (September 2017)

• Record Type: Journal Article
• Authors: Mironova, S.; Iudina, I.; Ionov, M.; Makhmatova, T.; Avdonina, N.; Emelyanov, I.; Zvartau, N.; Konradi, A.
• Is Part Of: Journal of hypertension. Volume 35(2017)Supplement 2
• Publication Date: 2017-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000523378.61282.4f
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Hypertension still remains one of the leading causes of end-stage renal disease, and early detection of kidney injury may affect treatment strategy and patient's prognosis. Serum creatinine with following estimation of glomerular filtration rate (eGFR) are the most commonly used markers of renal function, though they are frequently delayed and influenced by multiple non-renal factors, including gender. The aim of the present study was to compare conventional and novel, potentially more sensitive biomarkers of kidney injury in hypertensive patients of different gender. Design and method: Urine levels of neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), liver fatty-acid binding protein (L-FABP) and serum levels of Cystatin C (sCys) and creatinine (sCr) were measured by quantitative enzyme immunoassay in 92 hypertensive patients, 46 males (mean age 46, 3 ± 13, 4 years) and 46 females (mean age 55, 2 ± 8, 9 years). Renal function was analyzed using MDRD and the CKD Epidemiology Collaboration (EPI) sCr equation and CKD-EPI sCys equation. Instrumental examination was performed after 5 days of discontinuation of antihypertensive medications including ambulatory blood pressure monitoring (ABPM, SpaceLabs 90207), applanation tonometry (SphygmoCor, Artcor Medical) with the calculation of central aortic pressure. Results: Female patients were characterized by higher NGAL (16.6 +/− 12.8 versus 6.0 +/− 4.3 ng/ml, respectively; p = 0.0001) and lower sCys-estimated GFR (88.0 +/− 14.1 mL/min/1.73 m 2 versus 95.6 +/− 19.1; p = 0.04), while there were no differences in sCr-estimated GFR, KIM-1, L-FABP and Cystatin C levels between gender subgroups. Higher NGAL concentrations in females were associated with mean 24-hours systolic blood pressure (BP) level (r = 0.269, p = 0.06), sCys-estimated GFR - with mean night systolic BP and central systolic BP (r = −0, 356, p = 0.03; r = −0.302, p = 0.05, respectively). Conclusions: NGAL and sCys-estimated GFR seemed to be potentially earlier and more sensitive biomarkers of kidney injury compared to conventional serum creatinine level and sCr-estimated GFR and are associated with blood pressure levels in hypertensive females.