[PP.05.09] THE EFFECT OF CATHETER BASED RENAL SYMTHETIC DENERVATION ON RENIN-ANGIOTENSION-ALDOSTERONE SYSTEM IN PATIENTS WITH RESISTANT HYPERTENSION. (September 2017)

• Record Type: Journal Article
• Authors: Xu, M.; Lu, C.
• Is Part Of: Journal of hypertension. Volume 35(2017)Supplement 2
• Publication Date: 2017-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000523312.46927.c6
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: To explore the effect of catheter based renal symthetic denervation on renin-angiotension-aldosterone system (RAAS) and blood pressure reduction in patients with resistant hypertension, and assess the validity and security of the treatment. Design and method: Ten patients with resistant hypertension from June 2011 to December 2011 were retrospectively reviewed, and then all of ten patients screened for eligibility were allocated to renal denervation. Primary endpoints were changes of office blood pressure at 1 week, 1, 3 and 6 months after procedure. We assessed the effectiveness of renal sympathetic denervation with heart rate (HR), renin activity (PRA), angiotension II (Ang II), aldosterone (Ald), and cretinine (Cr) before and 2 weeks after procedure. Results: Office blood pressure after catherter-based renal denervation decreased by 22.8/9.1mmHg (1mmHg = 0.133kPa), 34.8/14.7mmHg, 42.6/20.7mmHg, 43.2/21.6mmHg, at 1 week, 1, 3 and 6 months, respectively (P < 0.001). Meanwhile, the level of PRA, Ang II, Ald decreased by (1.11 ± 0.89)ngml-1h-1 (P = 0.003), (17.06 ± 13.82) ng/L (P = 0.004), (404.5 ± 285.8) ng/L (P = 0.002), respectively; and heart rate decreased by 5.1 bpm (P = 0.002). However, the Cr level and eGFR did not change significantly (P > 0.05). Conclusions: Catheter-based renal sympathetic denervation can reduce the level of renin activity, angiotension II and aldosterone, and causes substantial and sustained blood-pressure reduction.