[PP.05.28] RELATIONSHIP BETWEEN UROCORTIN 2 CONCENTRATION AND METABOLIC PROFILE IN HEALTHY SUBJECTS. (September 2017)

• Record Type: Journal Article
• Authors: Siga, O.; Dzieza-Grudnik, A.; Walczewska, J.; Wolkow, P.; Borys, A.; Wizner, B.; Gryglewska, B.; Grodzicki, T.
• Is Part Of: Journal of hypertension. Volume 35(2017)Supplement 2
• Publication Date: 2017-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000523326.09703.2f
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: The aim of this study was to assess the relationship between the serum concentration of urocortin 2 (UCN 2) and metabolic parameters in healthy individuals. Design and method: We examined 37 middle age healthy subjects. Evaluation included anthropometric measurements (body mass index-BMI, waist to hip ratio-WHR) and ambulatory blood pressure monitoring (ABPM) using SpaceLabs 90207, 90217. Moreover we evaluated metabolic parameters in blood serum after ten hours of fasting: glucose, total cholesterol, low-density cholesterol (LDL), high density cholesterol (HDL), triglycerides (TG), HbA1c, insulin, hsCRP, NTproBNP. Glomerular filtration rate was estimated using the MDRD equation. For the analysis of UCN 2 concentration in blood of enrolled individuals we use ELISA Kit for UCN 2 (Cloud-Clone, USA). We divided the surveyed subjects into two groups according to the urocortin's median value (9, 12 ng/ml). The comparative analyses between the independent groups were based on the student's T-test, U Mann-Whitney and Chi2. To examine the relationships between selected parameters we used Pearson and Spearman correlations. Results: Mean age of the subjects was 45 ± 9, 2, about 35% were male. Median of UCN 2 concentration was 9, 12 ng/ml (IQR 7, 23-15, 05). Figure. No caption available. There were no significant differences between examined groups in age, sex, BMI, WHR, values of blood pressure and biochemical parameters like: glucose, HbA1c, insulin, creatinine, eGFR, hsCRP, NTproBNP, cortisol (details are presented in table 1). We observed significant differences between the groups in total cholesterol, LDL and HDL. These groups did not differ in terms of statins intake. We observed an inverse relationship between UCN 2 levels and lipid values (total cholesterol r = −054, p < 0, 05 LDL r = −0, 4, p < 0, 05). We did not observed such associations with other metabolic parameters. Conclusions: Subjects with higher level of UCN 2 have lower concentration of total cholesterol, HDL and LDL, however changes in UCN 2 concentration were not associated with others metabolic parameters.