Percutaneous intratumoral injection of gemcitabine plus cisplatin mixed with fibrin glue for advanced pancreatic carcinoma: Case Report. Issue 37 (September 2017)

• Record Type: Journal Article
• Authors: Yang, Biao; He, Jian-ping; Yuan, Min-lan; Li, Wei; Jiao, He; You, Xin; Liu, Xing-rong; Zhao, Jian; Li, Chun-lin; Fu, Xiao-bo; Liao, Zheng-yin; Yi, Cheng
• Other Names: Gabazza. Esteban section editor.
• Is Part Of: Medicine. Volume 96:Issue 37(2017)
• Publication Date: 2017-09
• Subjects: cisplatin -- fibrin glue -- gemcitabine -- intratumoral injection -- pancreatic cancer; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000008018
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: The aim of this study was to determine the effectiveness of intratumoral injection of chemotherapeutics in improving the quality of life and survival of patients with pancreatic carcinoma. Patient concerns: We present a case series of 5 patients with unresectable pancreatic adenocarcinoma. Diagnoses: Patients diagnosed with unresectable poorly differentiated pancreatic ductal adenocarcinoma by intraoperative frozen biopsyor percutaneous biopsy. Interventions: Five patients with unresectable pancreatic adenocarcinoma received a computed tomography-guided percutaneous intratumoral injection of gemcitabine plus cisplatin mixed with fibrin glue. Outcomes: Mean overall survival was 16.2 ± 3.7 months. Local control rates were 100% and 80% at postoperative 3 and 6 months, respectively. Mean Visual Analogue Scale pain score decreased from 7.2 ± .84 preoperatively to 2 ± 1.22 at postoperative 4 weeks. There were no complications associated with the procedure. Lessons: Percutaneous intratumoral injection of gemcitabine plus cisplatin mixed with fibrin glue for advanced pancreatic may be safe and effective. Abstract : Supplemental Digital Content is available in the text