[OP.7A.09] UROCORTIN2 LEVELS IN PATIENTS WITH RESISTANT HYPERTENSION TREATED WITH ACEI OR ARB. (September 2017)

• Record Type: Journal Article
• Authors: Walczewska, J.; Siga, O.; Dzieza-Grudnik, A.; Wolkow, P.; Borys, A.; Krolczyk, J.; Wizner, B.; Gryglewska, B.; Grodzicki, T.
• Is Part Of: Journal of hypertension. Volume 35(2017)Supplement 2
• Publication Date: 2017-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000523146.82598.ff
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Urocortin 2 (Ucn2) has powerful hemodynamic, renal, and neurohormonal actions and likely participates in normal circulatory homeostasis and the compensatory response to cardiovascular disorders. Lowering in blood pressure and in peripheral vascular resistance as well as vasodilating effect of ucn2 are considered to be important and interesting. It has been shown that there might be a relationship between ucn2 and ACE activity in circulation and tissues, thus suggesting that urocortin's vasorelaxation activity may be partially due to its effects on ACE activity and therefore Ang II levels. Changes of sACE activity, other RAAS components and hemodynamic status after administration of ucn2 to hypertensive rats suport the hypothesis of relationship between ucn2 and ACE in the vasodilation mechanism. So far there is no published data concerning ucn2 status in patients with hypertension receving farmacotherapy influencing on RAAS components. In our study we assessed the ucn2 serum level in individuals with resistant hypertension (RHT) treated with acei or arb. Design and method: 66 participants with resistant hypertension (treated at least 3 medications: acei/arb+ ccb+diuretic) were enrolled to the study. In all patients 24 ambulatory blood pressure monitoring ABPM, echocardiography, pulse wave velocity (PWV) as well as serum biochemistry and a serum concentration of urocortin2 were performed. Results: All participants were divided into two groups: receiving ACEI (n = 53) and ARB (n = 14). The ucn2 level was significantly higher in ACEI group compared to ARB group. There was no differences between groups in terms of clinical characteristics, serum biochemistry, other antihypertensive medications used. ACEI and ARB groups were also similar in value of 24 h ABPM, PWV, LVEF, but they differed in parameters of diastolic functions. The details are presented in the table. Figure. No caption available. Conclusions: Different level of serum ucn2 in ACEI and ARB groups may suggest a significant role of ucn2 in the mechanisms of RAAS blockade. Higher ucn2 serum level may also reflect a compensatory mechanism triggered by an early signs of diastolic function impairment in patients with essential hypertension.