[PP.01.02] METABOLICALLY HEALTHY OBESITY AS A PART OF THE CARDIOMETABOLIC CONTINUUM. (September 2017)

• Record Type: Journal Article
• Authors: Zhernakova, Y.; Azimova, M.; Trubacheva, I.; Kaveshnikov, V.; Serebryakova, V.; Rogoza, A.; Oschepkova, E.; Chazova, I.
• Is Part Of: Journal of hypertension. Volume 35(2017)Supplement 2
• Publication Date: 2017-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000523215.95991.24
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Was used data from epidemiological survey ESSE-RF (Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation) including adult population at the age of 25–64 y.o. of Siberian city Tomsk (n = 1538, including 58% females and 42% males). Design and method: Was used the systematic stratified multistage random sampling creating by the territorial principle of method by Keesh. Abdominal obesity (AO) was defined by waist circumference (WC) > 80 cm in women and 94 cm in men. MS was defined according to IDF, 2005. Diabetes mellitus 2 type (DM2) by fasting glucose > 6, 9 mmol/l or < 7 mmol/l with hypoglycemic therapy. Statistic data calculation was done with computer-based statistic software STATISTICA 10.0 and SPSS 14.0. Figure. No caption available. Results: Final analysis included 1538 persons. All examined persons have been divided into 4 groups depending on presence of obesity, metabolic syndrome (MS) and DM2, the 1st group included people without abdominal obesity (AO), MS and DM2 (n = 611). Patients with AO, but without MS (one additional risk factor was allowed) - metabolically healthy obese have been included into the 2nd group (n = 107). Patients with MS (n = 676) have been enrolled into the 3rd group. And patients with DM2 have been entered into the 4th group (n = 144). The prevalence of obesity in studied simple was 48, 1% by BMI > 30 kg/m 2 and 59% by WC. Arterial hypertension had 41, 7% respondents: 15, 4% in the 1st group, 32, 7% in the 2nd group, 75% in the 3rd group and 92, 3% in the 4th group. The prevalence of target organ damage (TOD) was growing from 1st group to 4th (Tab. 1). It was statistically significant (p < 0, 0001). Conclusions: Study results showed high prevalence of obesity, especially AO (59%) in the investigated population, prevalence of MS also was high (43%), as well as DM 2 (9, 3%). Cardiometabolic continuum (CC) is a progressive process and AO is fundamental to the pathophysiology of CC. Persons with metabolically healthy obesity already had the TOD. It could mean that AO without MS is a part of CC. Therefore patients with AO need more rigorous observe as early as possible.