[PP.01.12] THE ASSESSMENT OF THE ASSOCIATED CARDIOVASCULAR RISK FACTORS IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES. (September 2017)

• Record Type: Journal Article
• Authors: Tudorica, C.; Vintila, A.; Tudorica, S.; Vintila, V.; Bulei, C.; Gurghean, A.
• Is Part Of: Journal of hypertension. Volume 35(2017)Supplement 2
• Publication Date: 2017-09
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000523224.18863.58
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: To assess the presence of additional cardiovascular risk factors that could worsen long term prognosis in hypertensive and type 2 diabetes mellitus (T2DM) patients. Design and method: Patients with arterial hypertension and T2DM were assessed between January 2015 and September 2016 in a cross sectional study. We evaluated associated cardiovascular risk factors (dyslipidemia, obesity [BMI > 30 kg/m 2 ], smoking) and subclinical renal damage (microalbuminuria). Results: We evaluated 180 hypertensive patients withT2DM, 49.6% male, mean age 66.3 years, mean duration of T2DM 9, 6 years, mean HbA1c 8.6% (20% with HbA1c < 7%), mean duration of hypertension 12, 4 years, mean blood pressure 148/102 mmHg (35% controlled). Patients were treated with oral antidiabetics for T2DM and ACEi, ARBs, CCB, diuretics for hypertension. Mean BMI was 30.4 kg/m 2 . 50.4% of the patients were obese, 21.1% smokers. Mean values for lipid parameters were: 186 mg/dl total cholesterol, 108.7 mg/dl LDL-C, 44.1 mg/dl HDL-C and 174.4 mg/dl triglycerides. 90% of patients had LDL-C > 70 mg/dl in spite of treatment with statins. 24.6% of patients had a history of major cardiovascular events (more frequent in people with > 9 years duration of diabetes). In patients with microalbuminuria (30% of total number), mean duration of T2DM was 9.3 years, mean HbA1c 7.8% (40% with HbA1c < 7%), mean blood pressure 135/94 mmHg (35% controlled), mean BMI 31.7 kg/m 2 . 62.3% of patients were obese, 20.1% smokers. Mean value for cholesterol was 169.1 mg/dl, LDL-C 93.3 mg/dl, HDL-C 43.7 mg/dl and triglycerides 180.8 mg/dl. 68% of patients had LDL-C > 70 mg/dl in spite of treatment with statins. 30% of patients had a history of major cardiovascular events. Conclusions: Associated cardiovascular risk factors are frequent in patients with type 2 diabetes and hypertension. Unfortunately, more than 50% of all parameters are uncontrolled in the majority of patients. A better control was achieved in patients with microalbuminuria, potentially due to an increased adherence of the subjects being informed on the severity of their disease. Patients with type 2 diabetes and hypertension remain at increased risk of developing macrovascular and microvascular complications. Large benefits are likely to be seen when medication is addressed to multiple risk factors simultaneously.