Predictors of lymph nodes posterior to the right recurrent laryngeal nerve metastasis in patients with papillary thyroid carcinoma: A retrospective study. Issue 35 (September 2017)

• Record Type: Journal Article
• Authors: Yuan, Jiru; Li, Jinghua; Chen, Xiaoyi; Zhong, Zhenwei; Chen, Zhengbo; Yin, Ying; Du, Jialin; Cong, Shuzhen; Wu, Zeyu
• Other Names: Huang. Lei section editor.
• Is Part Of: Medicine. Volume 96:Issue 35(2017)
• Publication Date: 2017-09
• Subjects: central lymph node metastasis (CLNM) -- lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLN) -- papillary thyroid carcinoma (PTC); Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000007908
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: The aim of this study was to identify the risk factors associated with lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLN) metastasis in patients with papillary thyroid carcinoma (PTC). A total of 81 PTC patients who underwent total/near-total thyroidectomy with LN-prRLN dissection in the Department of General Surgery at Guangdong General Hospital between June 2015 and August 2016 were assessed retrospectively. The relations of LN-prRLN metastasis with clinicopathologic characteristics of PTC were analyzed by univariate and multivariate logistic regression. The incidence of LN-prRLN metastasis in patients with PTC was 51.9% (42 of 81 cases). Univariate analysis showed that lateral LN metastasis ( P = .005), VIa central LN metastasis ( P = .000), pathologic tumor size ( P = .000), capsular invasion ( P = .002), and extrathyroidal invasion ( P = .018) ( P < .05) were significantly associated with the increased incidence of LN-prRLN metastasis in PTC. No significant correlations were found between LN-prRLN metastasis and other variables such as gender ( P = .056), age ( P = .448), clinical N stage (cN) ( P = .063), tumor location ( P = .336), tumor site ( P = .909), right tumor existence ( P = .793), and multifocality ( P = .381). Multivariate logistic regression analysis revealed that VIa central LN metastasis (OR: 4.490, P = .027) was independent risk factors of LN-prRLN metastasis in patients with PTC. LN-prRLN metastasis is often indentified in patients with PTC. VIa central LN metastasis is an independent predictors of LN-prRLN metastasis, which allow for selective LN-prRLN dissection in patients with PTC.