Synthesis, Crystal Structure, DNA‐binding Properties and Antioxidant Activity of a Copper(II) Complex with Naphthalimide Schiff Base. Issue 18 (14th September 2017)

• Record Type: Journal Article
• Authors: Chen, Ying; Mao, Shanshan; Shi, Xinkui; Shen, Kesheng; Wu, Huilu
• Is Part Of: Zeitschrift für anorganische und allgemeine Chemie. Volume 643:Issue 18(2017)
• Page Start: 1182
• Page End: 1190
• Publication Date: 2017-09-14
• Subjects: Antioxidant activity -- Copper -- Crystal structure -- DNA‐binding property -- Naphthalimide Schiff base; Chemistry, Inorganic -- Periodicals; Chemistry -- Periodicals; 540
• DOI: 10.1002/zaac.201700207
• Languages: English
• ISSNs: 0044-2313

Abstract

Abstract : The Schiff N ‐allylamine‐4‐(ethylenediamine‐5‐methylsalicylidene)‐1, 8‐naphthalimide (H2 L) and its copper(II) complex, [Cu(HL)2 ]· 0.5DMF, were synthesized and characterized. The crystal structure of the Cu II complex reveals a slightly distorted square‐planar arrangement provided by two N and O donors from two deprotonated ligands. In addition, the DNA‐binding properties of the ligand and Cu II complex were investigated by fluorescence spectra, electronic absorption, and viscosity measurements. The experimental studies of the DNA‐binding properties indicated that the ligand and Cu II complex reacted with DNA via intercalation binding mode, and binding affinity for DNA takes the order: ligand > Cu II complex. The antioxidant assay in vitro suggested that both exhibited potential intensely antioxidant properties, and the ligand is more effective than its Cu II complex. Abstract :