Matrix‐assisted diffusion‐ordered spectroscopy: choosing a matrix. (7th June 2016)

• Record Type: Journal Article
• Authors: Gramosa, Nilce V.; Ricardo, Nágila M. S. P.; Adams, Ralph W.; Morris, Gareth A.; Nilsson, Mathias
• Is Part Of: Magnetic resonance in chemistry. Volume 54:Number 10(2016:Oct.)
• Page Start: 815
• Page End: 820
• Publication Date: 2016-06-07
• Subjects: NMR -- 1H -- DOSY -- matrix‐assisted DOSY -- MAD -- dihydroxybenzene isomers -- Brij -- SDS -- CTAB; Nuclear magnetic resonance spectroscopy -- Periodicals; Chemistry, Organic -- Periodicals; Magnetic resonance -- Periodicals; 538.36
• DOI: 10.1002/mrc.4459
• Languages: English
• ISSNs: 0749-1581

Abstract

Abstract : Diffusion‐ordered spectroscopy (DOSY) is an important technique for separating the NMR signals of the components in a mixture, and relies on differences in diffusion coefficient. Standard DOSY experiments therefore struggle when the components of a mixture are of similar size, and hence diffuse at similar rates. Fortunately, the diffusion coefficients of solutes can be manipulated by changing the matrix in which they diffuse, using matrix components that interact differentially with them, a technique known as matrix‐assisted DOSY. In the present investigation, we evaluate the performance of a number of new, previously used, and mixed matrices with an informative test mixture: the three positional isomers of dihydroxybenzene. The aim of this work is to present the matrix‐assisted DOSY user with information about the potential utility of a set of matrices (and combinations of matrices), including ionic and non‐ionic surfactants, complexing agents, polymers, and mixed solvents. A variety of matrices improved the diffusion resolution of the signals of the test system, with the best separation achieved by mixed micelles of sodium dodecyl sulfate and cetyl trimethylammonium bromide. The use of mixed matrices offers great potential for the analyst to tailor the matrix to a particular sample under study. © 2016 The Authors Magnetic Resonance in Chemistry Published by John Wiley & Sons, Ltd. Abstract : Matrix‐assisted diffusion‐ordered spectroscopy is a useful technique for separating the NMR signals of the components in a mixture when the components have very similar diffusion coefficients. These diffusion coefficients can be manipulated by changing the matrix in which they diffuse, exploiting interactions between matrix and solute. In the present investigation we evaluate the performance of a number of new, previously used, and mixed matrices with an informative test mixture.