A living electrode construct for incorporation of cells into bionic devices. (27th June 2017)

• Record Type: Journal Article
• Authors: Goding, Josef; Gilmour, Aaron; Robles, Ulises Aregueta; Poole-Warren, Laura; Lovell, Nigel; Martens, Penny; Green, Rylie
• Is Part Of: MRS communications. Volume 7:Number 3(2017)
• Page Start: 487
• Page End: 495
• Publication Date: 2017-06-27
• Subjects: Materials -- Periodicals; 620.11
• DOI: 10.1557/mrc.2017.44
• Languages: English
• ISSNs: 2159-6859

Abstract

Abstract: Abstract : A living electrode construct that enables integration of cells within bionic devices has been developed. The layered construct uses a combination of non-degradable conductive hydrogel and degradable biosynthetic hydrogel to support cell encapsulation at device surfaces. In this study, the material system is designed and analyzed to understand the impact of the cell carrying component on electrode characteristics. The cell carrying layer is shown to provide a soft interface that supports extracellular matrix development within the electrode while not significantly reducing the charge transfer characteristics. The living layer was shown to degrade over 21 days with minimal swelling upon implantation.