Analysis of the skin of mice humanized for the immune system. Issue 10 (10th April 2017)

• Record Type: Journal Article
• Authors: Centlivre, Mireille; Petit, Maxime; Hutton, Andrew J.; Dufossée, Mélody; Boccara, David; Mimoun, Maurice; Soria, Angèle; Combadière, Béhazine
• Is Part Of: Experimental dermatology. Volume 26:Issue 10(2017)
• Page Start: 963
• Page End: 966
• Publication Date: 2017-04-10
• Subjects: antigen‐presenting cells -- human immune system mice -- intra‐dermal vaccination -- route of administration -- skin T cells; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/exd.13340
• Languages: English
• ISSNs: 0906-6705

Abstract

Abstract: Development of new immunotherapeutic strategies relies on the ability to activate the right cells at the right place and at the right moment and on the capacity of these cells to home to the right organ(s). Skin delivery has shown high potency for immunotherapeutic administration. However, an adequate in vivo model of human skin immunity is still a critical bottleneck. We demonstrated here that the skin of human immune system mice is colonized by human hematopoietic cells, mainly human T cells and that complementation with human antigen‐presenting cells at the vaccination site allowed the induction of an immune response.