Can serum NGAL levels be used as an inflammation marker on hemodialysis patients with permanent catheter?. (27th October 2014)

• Record Type: Journal Article
• Authors: Yigit, Irem Pembegul; Celiker, Huseyin; Dogukan, Ayhan; Ilhan, Necip; Gurel, Ali; Ulu, Ramazan; Aygen, Bilge
• Is Part Of: Renal failure. Volume 37:Number 1(2015)
• Page Start: 77
• Page End: 82
• Publication Date: 2014-10-27
• Subjects: Central venous permanent catheter -- hemodialysis -- interleukin-6 -- neutrophil gelatinase-associated lipocalin -- tumor necrosis factor-alpha; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2014.975133
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: Background : Neutrophil gelatinase-associated lipocalin (NGAL) is a member of lipocalin family and released from many tissues and cells. We aimed to investigate the relationship among serum NGAL levels, the inflammation markers (IL-6, hs-CRP, TNF-α) and different vascular access types used in dialysis patients. Methods : The study population included 90 patients and 30 healthy age-matched controls. The patients were divided into three groups (I, II, III) and group IV included the controls. In group I and II, the patients were with central venous permanent catheter and arterio-venous fistula, respectively. Group III included 30 patients with chronic renal failure. Hemogram, biochemical assays, ferritin, IL-6, hs-CRP, TNF-α, and NGAL were evaluated in all groups. Results : Serum NGAL levels were markedly higher in group I than in group II (7645.80 ± 924.61 vs. 4131.20 ± 609.87 pg/mL; p < 0.05). Positive correlation was detected between NGAL levels and duration of catheter ( r : 0.903, p : 0.000), hs-CRP ( r : 0.796, p : 0.000), IL-6 ( r : 0.687, p : 0.000), TNF-α ( r : 0.568, p : 0.000) levels and ferritin ( r : 0.318, p : 0.001), whereas NGAL levels were negatively correlated with serum albumin levels ( r : −0.494, p : 0.000). In multiple regression analysis, duration of catheter hs-CRP and TNF-α were predictors of NGAL in hemodialysis patients. Conclusion : Inflammation was observed in hemodialysis patients and increases with catheter. Our findings show that a strong relationship among serum NGAL levels, duration of catheter, hs-CRP and TNF-α. NGAL may be used as a new inflammation marker in hemodialysis patients.