First experience of liver transplantation with type 2 donation after cardiac death in France. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Savier, Eric; Dondero, Federica; Vibert, Eric; Eyraud, Daniel; Brisson, Hélène; Riou, Bruno; Fieux, Fabienne; Naili‐Kortaia, Salima; Castaing, Denis; Rouby, Jean‐Jacques; Langeron, Olivier; Dokmak, Safi; Hannoun, Laurent; Vaillant, Jean‐Christophe
• Is Part Of: Liver transplantation. Volume 21:Issue 5(2015:May)
• Page Start: 631
• Page End: 643
• Publication Date: 2015-05
• Subjects: Liver -- Transplantation -- Periodicals; Liver -- Diseases -- Periodicals; Liver Transplantation -- Periodicals; Foie -- Greffe -- Périodiques; 617.5560592
• DOI: 10.1002/lt.24107
• Languages: English
• ISSNs: 1527-6465

Abstract

Abstract : Organ donation after unexpected cardiac death [type 2 donation after cardiac death (DCD)] is currently authorized in France and has been since 2006. Following the Spanish experience, a national protocol was established to perform liver transplantation (LT) with type 2 DCD donors. After the declaration of death, abdominal normothermic oxygenated recirculation was used to perfuse and oxygenate the abdominal organs until harvesting and cold storage. Such grafts were proposed to consenting patients < 65 years old with liver cancer and without any hepatic insufficiency. Between 2010 and 2013, 13 LTs were performed in 3 French centers. Six patients had a rapid and uneventful postoperative recovery. However, primary nonfunction occurred in 3 patients, with each requiring urgent retransplantation, and 4 early allograft dysfunctions were observed. One patient developed a nonanastomotic biliary stricture after 3 months, whereas 8 patients showed no sign of ischemic cholangiopathy at their 1‐year follow‐up. In comparison with a control group of patients receiving grafts from brain‐dead donors (n = 41), donor age and cold ischemia time were significantly lower in the type 2 DCD group. Time spent on the national organ wait list tended to be shorter in the type 2 DCD group: 7.5 months [interquartile range (IQR), 4.0‐11.0 months] versus 12.0 months (IQR, 6.8‐16.7 months; P = 0.08. The 1‐year patient survival rates were similar (85% in the type 2 DCD group versus 93% in the control group), but the 1‐year graft survival rate was significantly lower in the type 2 DCD group (69% versus 93%; P = 0.03). In conclusion, to treat borderline hepatocellular carcinoma, LT with type 2 DCD donors is possible as long as strict donor selection is observed. Liver Transpl 21:631‐643, 2015 . © 2015 AASLD.