The influence of spray cryotherapy on wound healing following endoscopic sinus surgery in chronic rhinosinusitis. (17th March 2015)

• Record Type: Journal Article
• Authors: Albu, Silviu; Trombitas, Veronica; Vlad, Diana; Emanuelli, Enzo
• Is Part Of: Laryngoscope. Volume 126:Number 1(2016:Jan.)
• Page Start: 25
• Page End: 32
• Publication Date: 2015-03-17
• Subjects: Wound healing -- endoscopic sinus surgery -- cryotherapy; Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.25257
• Languages: English
• ISSNs: 0023-852X

Abstract

Abstract : Objectives/Hypothesis: The aim of this study was to assess the influence of spray cryotherapy on wound healing following endoscopic sinus surgery (ESS). Study Design: A prospective, randomized, double‐blinded, controlled trial. Methods: The study included 22 consecutive adult patients with chronic rhinosinusitis with and without polyps scheduled for bilateral ESS. At the end of the surgical procedure, patients were randomized to the distribution of spray cryotherapy in one middle meatus and saline contralaterally. Outcomes were only measured for endoscopy scores. Thus, postoperative healing and the amount of edema, crusting, secretions, and scarring were assessed using the validated Lund‐Kennedy and Perioperative Sinus Endoscopy (POSE) scores. Results: There were no baseline differences concerning POSE and Lund‐Kennedy scores between the two groups. Nevertheless, a significant difference was recorded at one, 2, 4, 8, and 12 weeks in both POSE ( P = .001, P = .012, P = .02, P = .006, P = .001) and Lund‐Kennedy ( P = .002, P = .005, P = .02, P = .02, P = .03) scores. Conclusions: These preliminary results reveal an improvement in postoperative scores, demonstrating enhanced healing following spray cryotherapy. However, without patient subjective outcomes, the study is limited. Additional studies with longer follow‐up and larger samples are needed to describe the effects of cryotherapy on wound healing. Level of Evidence: 1b. Laryngoscope, 126:25–32, 2016