CRP relevance in clinical assessment of chronic spontaneous urticaria Tunisian patients. (2nd October 2017)

• Record Type: Journal Article
• Authors: Maouia, A.; Youssef, M.; Leban, N.; Ben Chibani, J.; Helal, A. N.; Kassab, A.
• Is Part Of: Cutaneous and ocular toxicology. Volume 36:Number 4(2017)
• Page Start: 387
• Page End: 392
• Publication Date: 2017-10-02
• Subjects: Chronic spontaneous urticaria -- desloratadine -- inflammation -- oxidative stress; Dermatotoxicology -- Periodicals; Ocular toxicology -- Periodicals; Ocular pharmacology -- Periodicals; Dermatopharmacology -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1080/15569527.2017.1311338
• Languages: English
• ISSNs: 1556-9527

Abstract

Abstract: Background : Chronic spontaneous urticaria (CSU) is a common dermatological condition defined by the sudden occurrence of daily wheals and pruritus for at least six weeks. Multifactorial origin is suggested such as oxidative stress. This latter may play a double role as a trigger and remnant agent. Objectives : The first aim of this study is to investigate antioxidant status, inflammatory proteins, hematologic counts and clinical assessment in CSU patients. The second aim is to evaluate the effect of a first-line treatment: desloratadine 5 mg/d on these different parameters. Patients and Methods : This study enrolled 30 CSU patients and same number of controls. We assessed the urticaria activity score (UAS), total antioxidant status (TAS), glutathione S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), albumin, alpha1, alpha2, beta1 beta2, gamma globulins, c-reactive protein (CRP) and hematologic numeration. Results : At baseline alpha1, alpha2, beta1, beta2, gamma globulins, CRP, SOD activity, leukocytes and basophils were significantly higher in patients versus controls ( p < 0.05). TAS, GST, CAT, GPx and albumin were significantly low in patients versus controls ( p < 0.05). After treatment, TAS, GST and GPx were significantly increased in patients versus patients before treatment ( p < 0.001). SOD, alpha1, alpha2, beta1, beta2, gamma globulins, CRP, albumin, leukocytes and basophils were significantly decreased after treatment versus before treatment ( p < 0.05). A significant correlation between CRP and UAS ( r = 0.3; p = 0.011) was noted. UAS assessment revealed the efficacy of 30 d-antihistaminic treatment. Conclusions : Desloratadine exerted anti-inflammatory and antioxidant effects on CSU patients revealed by CRP. Patients' remission was synergistic to CRP attenuation emphasizing CRP relevance for CSU clinical assessment.