Ketonuria may be associated with low serum amylase independent of body weight and glucose metabolism. (20th October 2017)

• Record Type: Journal Article
• Authors: Nakajima, Kei; Oda, Eiji
• Is Part Of: Archives of physiology and biochemistry. Volume 123:Number 5(2017)
• Page Start: 293
• Page End: 296
• Publication Date: 2017-10-20
• Subjects: Ketonuria -- lipids -- carbohydrates -- amylase -- obesity -- diabetes; Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.1080/13813455.2017.1326941
• Languages: English
• ISSNs: 1381-3455

Abstract

Abstract: Context: Ketonuria, which reflects a preferential combustion of lipids relative to carbohydrates, is often observed in lean rather than obese people. Clinical studies have shown that individuals with diabetes and/or obesity predispose to have low serum amylase (LSA). Objective: To investigate the association between ketonuria and LSA. Methods: We examined ketonuria assessed by dipstick urinalysis and clinical parameters including serum amylase in 3638 Japanese people aged 25–79 years who underwent a health-screening checkup. Results: There was an inverse relationship between body mass index (BMI) and serum amylase. The lowest serum amylase was observed in obese subjects (BMI ≥ 25.0 kg/m 2 ) with positive ketonuria. Logistic regression analysis showed that ketonuria was significantly associated with LSA (<50 IU/L), which was not altered by the adjustments for relevant confounders including age, sex, BMI, and HbA1c. Conclusions: Current results suggest a relative unavailability of carbohydrates for energy production in individuals with LSA.