K2CO3-promoted aerobic oxidative cross-coupling of trialkyl phosphites with thiophenols. Issue 72 (25th September 2017)

• Record Type: Journal Article
• Authors: Wen, Chunxiao; Chen, Qian; Huang, Yulin; Wang, Xiaofeng; Yan, Xinxing; Zeng, Jiekun; Huo, Yanping; Zhang, Kun
• Is Part Of: RSC advances. Volume 7:Issue 72(2017)
• Page Start: 45416
• Page End: 45419
• Publication Date: 2017-09-25
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra09057a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Phosphorylation of thiols has been achieved via K2 CO3 -promoted aerobic oxidative cross-coupling of trialkyl phosphites with thiophenols. Abstract : Convenient, practical and economical phosphorylation of thiols has been achieved via halogen- and metal-free K2 CO3 -promoted aerobic oxidative cross-coupling of trialkyl phosphites, dimethyl phenylphosphonite, or methyl diphenylphosphinite with thiophenols using air as the oxidant at room temperature. This transformation provides a straightforward route to the construction of phosphorus–sulfur bonds with wide functional group compatibility, which affords phosphorothioates in up to 94% yield.