Novel spirocyclic systems via multicomponent aza-Diels–Alder reaction. Issue 37 (11th September 2017)

• Record Type: Journal Article
• Authors: Llona-Minguez, Sabin; Throup, Adam; Steiner, Emilie; Lightowler, Molly; Van der Haegen, Sandra; Homan, Evert; Eriksson, Lars; Stenmark, Pål; Jenmalm-Jensen, Annika; Helleday, Thomas
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 37(2017)
• Page Start: 7758
• Page End: 7764
• Publication Date: 2017-09-11
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob02069d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels–Alder reaction. Abstract : Here we present a two-step diastereoselective methodology building on a multicomponent aza-Diels–Alder reaction. Using previously unexplored cyclic ketones, heterocyclic amines and cyclopentadiene derivatives, we obtained novel spiro-heterocyclic frameworks at the interphase between "drug-like" molecules and natural products.