Enantioselective electrophilic cyanation of β-keto amides catalysed by a cinchona organocatalyst. Issue 37 (11th September 2017)

• Record Type: Journal Article
• Authors: Karmaker, Pran Gopal; Qiu, Jiashen; Wu, Di; Reng, Mengmeng; Yang, Zhuo; Yin, Hongquan; Chen, Fu-Xue
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 37(2017)
• Page Start: 7753
• Page End: 7757
• Publication Date: 2017-09-11
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob01782k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An operationally simple protocol for the enantioselective electrophilic α-cyanation of β-keto amides catalyzed by cinchona-derived catalysts has been demonstrated. Abstract : An operationally simple protocol for the enantioselective electrophilic α-cyanation of β-keto amides catalyzed by cinchona-derived catalysts has been demonstrated. The resulting products could be obtained with good to high enantioselectivities (up to 88% ee) and with excellent yields (up to 94%) by employing the mild active 4-acetylphenyl cyanate as the cationic cyano source in the catalytic asymmetric α-cyanation reaction.