A highly enantioselective asymmetric Darzens reaction catalysed by proline based efficient organocatalysts for the synthesis of di- and tri-substituted epoxides. Issue 79 (20th September 2017)

• Record Type: Journal Article
• Authors: Ashokkumar, Veeramanoharan; Siva, Ayyanar; Ramaswamy Chidambaram, R.
• Is Part Of: Chemical communications. Volume 53:Issue 79(2017)
• Page Start: 10926
• Page End: 10929
• Publication Date: 2017-09-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc06194c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A new class of proline based chiral organocatalysts was designed and efficient catalysts for asymmetric Darzens reaction to obtain active di- and tri-substituted epoxides with high yields (up to 97%) and excellent ee's (up to 99%) under mild reaction conditions. Abstract : A new class of easily available and readily tunable proline based chiral organocatalysts was found to efficiently catalyse an unprecedented highly enantioselective asymmetric Darzens reaction of α-chloroketones and substituted α-chloroketones with various aldehydes, which directly produces optically active di- and tri-substituted chiral epoxides with higher product yields (up to 97%) and excellent ee's (up to 99%) under mild reaction conditions.