Primary cutaneous CD4‐positive small/medium‐sized pleomorphic T‐cell lymphoproliferative disorder: Report of a case and review of the literature. (30th August 2017)

• Record Type: Journal Article
• Authors: Keeling, Brett H.; Gavino, Alde Carlo P.; Admirand, Joan; Soldano, Anthony C.
• Is Part Of: Journal of cutaneous pathology. Volume 44:Number 11(2017)
• Page Start: 944
• Page End: 947
• Publication Date: 2017-08-30
• Subjects: lymphoma -- lymphoproliferative disorder -- lymphoid neoplasms -- dermatology; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.13011
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract : Primary cutaneous small/medium‐sized T‐cell lymphoma (PCSM‐TCL), which was included in the World Health Organization ‐ European Organization for Research and Treatment of Cancer (WHO‐EORTC) classification for cutaneous lymphomas as a provisional entity in 2008, has recently been reclassified as primary cutaneous small/medium‐sized T‐cell lymphoproliferative disorder (PCSM‐TCLPD) because of its indolent behavior and uncertain malignant potential. Treatment with local therapies is usually curative, although there have been reports of aggressive, systemic disease. This spectrum of disease behavior evokes the consideration that this entity may actually be multiple diseases with a shared clinicopathologic features rather than a singular disease process with a variety of behaviors. PCSM‐TCLPD retained its designation as a provisional entity under the updated WHO‐EORTC guidelines; however, additional cases of PCSM‐TCLPD are needed to shed more light on this rare disorder.