Biological properties of propolis extracts: Something new from an ancient product. (October 2017)

• Record Type: Journal Article
• Authors: Zabaiou, Nada; Fouache, Allan; Trousson, Amalia; Baron, Silvère; Zellagui, Amar; Lahouel, Mesbah; Lobaccaro, Jean-Marc A.
• Is Part Of: Chemistry and physics of lipids. Volume 207(2017)Part B
• Page Start: 214
• Page End: 222
• Publication Date: 2017-10
• Subjects: DHT 5α-dihydrotestosterone -- ABCA1 ATP-binding cassette A1 -- AR androgen receptor -- cIAP-2 baculoviral IAP repeat-containing protein3 -- Bax Bcl-2-associated X protein -- CAPE caffeic acid phenethyl ester -- ERK extracellular signal-regulated kinases -- IL1-β interleukin 1-β -- LXRs liver X receptors -- MMP matrix metalloproteinases -- NFκB nuclear factor kappa-light-chain-enhancer of activated B cells -- TLR toll-like receptor -- p70S6K ribosomal protein S6 kinase beta-1 -- cTAP-1 transporter associated with antigen processing 1 -- TNFα tumor necrosis factor α -- TRAIL tumor necrosis factor related apoptosis inducing ligand -- u-PA urokinase-type plasminogen activator -- XIAP X-linked inhibitor of apoptosis protein; Propolis -- Flavonoids -- Prostate cancer -- Ethanolic extracts -- Traditional therapy; Lipids -- Periodicals; Lipids -- Periodicals; Lipides -- Périodiques; Lipids; Periodicals; Electronic journals; 547.77
• DOI: 10.1016/j.chemphyslip.2017.04.005
• Languages: English
• ISSNs: 0009-3084

Abstract

Highlights: Propolis has been used for centuries in folk medicine. It rich in antioxidant molecules. It has antibacterial, antifungal and anti-inflammatory properties. It has positive effects in models of neurodegenerative diseases. Propolis is of a great interest in the field of anti-cancer therapy. Abstract: Natural products are an interesting source of new therapeutics, especially for cancer therapy as 70% of them have botany origin. Propolis, a resinous mixture that honey bees collect and transform from tree buds, sap flows, or other botanical sources, has been used by ethnobotany and traditional practitioners as early in Egypt as 3000 BCE. Enriched in flavonoids, phenol acids and terpene derivatives, propolis has been widely used for its antibacterial, antifungal and anti-inflammatory properties. Even though it is a challenge to standardize propolis composition, chemical analyses have pointed out interesting molecules that also present anti-oxidant and anti-proliferative properties that are of interest in the field of anti-cancer therapy. This review describes the various geographical origins and compositions of propolis, and analyzes how the main compounds of propolis could modulate cell signaling. A focus is made on the putative use of propolis in prostate cancer.