Diterpenes with Unprecedented Skeletons from the Red Alga Sphaerococcus coronopifolius. Issue 13 (20th March 2015)

• Record Type: Journal Article
• Authors: Smyrniotopoulos, Vangelis; Kiss, Robert; Mathieu, Véronique; Vagias, Constantinos; Roussis, Vassilios
• Is Part Of: European journal of organic chemistry. Issue 13(2013)
• Page Start: 2848
• Page End: 2853
• Publication Date: 2015-03-20
• Subjects: Natural products -- Terpenoids -- Diterpenes -- Structure elucidation; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201500133
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: Three previously unknown diterpenes – spirosphaerol (1 ), anthrasphaerol (2 ) and corfusphaeroxide (3 ) – have been isolated from the red alga Sphaerococcus coronopifolius . Their structures were elucidated by spectral analysis, including NMR and MS. The isolated metabolites were evaluated for their in vitro antitumour activities against one murine and five human cancer cell lines. Abstract : Chemical investigation of the red alga Sphaerococcus coronopifolius led to the isolation and structure elucidation of the three new minor metabolites1 –3, featuring rearranged tricyclic diterpene skeletons. The in vitro antitumour activities of1 –3 were evaluated against one murine cancer cell line and five human cancer cell lines.