Optimization of a Planar All‐Polymer Transistor for Characterization of Barrier Tissue. Issue 6 (5th March 2015)

• Record Type: Journal Article
• Authors: Ramuz, Marc; Margita, Kaleigh; Hama, Adel; Leleux, Pierre; Rivnay, Jonathan; Bazin, Ingrid; Owens, Róisín M.
• Is Part Of: Chemphyschem. Volume 16:Issue 6(2015)
• Page Start: 1210
• Page End: 1216
• Publication Date: 2015-03-05
• Subjects: barrier tissue -- conducting polymers -- electrochemistry -- organic electrochemical transistors -- sensors; Chemistry, Physical and theoretical -- Periodicals; 541.05
• DOI: 10.1002/cphc.201402878
• Languages: English
• ISSNs: 1439-4235

Abstract

Abstract: The organic electrochemical transistor (OECT) is a unique device that shows great promise for sensing in biomedical applications such as monitoring of the integrity of epithelial tissue. It is a label‐free sensor that is amenable to low‐cost production by roll‐to‐roll or other printing technologies. Herein, the optimization of a planar OECT for the characterization of barrier tissue is presented. Evaluation of surface coating, gate biocompatibility and performance, and optimization of the geometry of the transistor are highlighted. The conducting polymer poly(3, 4‐ethylenedioxythiophene):poly(styrene sulfonate), which is used as the active material in the transistor, has the added advantage of allowing significant light transmission compared to traditional electrode materials and thus permits high‐quality optical microscopy. The combination of optical and electronic monitoring of cells shown herein provides the opportunity to couple two very complementary techniques to yield a low‐cost method for in vitro cell sensing. Abstract : Organic electrochemical transistor: A planar organic electrochemical transistor is optimized for the characterization of barrier tissue. Using a transparent conducting polymer as the active material in the transistor allows simultaneous optical and electrical monitoring of the barrier. Thus, two complementary techniques are combined in a low‐cost method for in vitro cell sensing.