Calcium Signaling and Transcriptional Regulation in Cardiomyocytes. Issue 8 (29th September 2017)

• Record Type: Journal Article
• Authors: Dewenter, Matthias; von der Lieth, Albert; Katus, Hugo A.; Backs, Johannes
• Is Part Of: Circulation research. Volume 121:Issue 8(2017)
• Publication Date: 2017-09-29
• Subjects: calcium -- calcium-calmodulin dependent protein kinase II -- calcineurin -- calmodulin -- excitation transcription coupling; Cardiovascular system -- Periodicals; Blood -- Circulation -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; Sang -- Circulation -- Périodiques; Appareil cardiovasculaire -- Périodiques; 612.1
• DOI: 10.1161/CIRCRESAHA.117.310355
• Languages: English
• ISSNs: 0009-7330

Abstract

Abstract : Calcium (Ca 2+ ) is a universal regulator of various cellular functions. In cardiomyocytes, Ca 2+ is the central element of excitation–contraction coupling, but also impacts diverse signaling cascades and influences the regulation of gene expression, referred to as excitation–transcription coupling. Disturbances in cellular Ca 2+ -handling and alterations in Ca 2+ -dependent gene expression patterns are pivotal characteristics of failing cardiomyocytes, with several excitation–transcription coupling pathways shown to be critically involved in structural and functional remodeling processes. Thus, targeting Ca 2+ -dependent transcriptional pathways might offer broad therapeutic potential. In this article, we (1) review cytosolic and nuclear Ca 2+ dynamics in cardiomyocytes with respect to their impact on Ca 2+ -dependent signaling, (2) give an overview on Ca 2+ -dependent transcriptional pathways in cardiomyocytes, and (3) discuss implications of excitation–transcription coupling in the diseased heart.