Magnetic Resonance Imaging–Based Prostate-Specific Antigen Density for Prediction of Gleason Score Upgrade in Patients With Low-Risk Prostate Cancer on Initial Biopsy. Issue 5 (September 2017)

• Record Type: Journal Article
• Authors: Sim, Ki Choon; Sung, Deuk Jae; Kang, Kun Woo; Yang, Kyung Sook; Han, Na Yeon; Park, Beom Jin; Kim, Min Ju; Cho, Sung Bum
• Is Part Of: Journal of computer assisted tomography. Volume 41:Issue 5(2017)
• Publication Date: 2017-09
• Subjects: Gleason score -- magnetic resonance imaging -- prostate cancer -- prostate-specific antigen; Tomography -- Periodicals; Tomography -- Periodicals; Tomography; Periodicals; 616.0757
• DOI: 10.1097/RCT.0000000000000579
• Languages: English
• ISSNs: 0363-8715

Abstract

Abstract : Objective: The aim of this study was to assess the utility of prostate-specific antigen density (PSAD) calculated using magnetic resonance imaging for predicting Gleason score (GS) upgrade in patients with low-risk prostate cancer on biopsy. Methods: Seventy-three patients were divided into 2 groups according to the concordance between biopsy and prostatectomy GS: group 1 (6/6) and group 2 (6/≥7). Magnetic resonance imaging–based PSAD, prostate volume, prostate-specific antigen (PSA), and age were compared between the 2 groups. Logistic regression and receiver operating characteristic curve analysis were performed. Results: Gleason score was upgraded in 40 patients. Patients in group 2 had significantly higher PSAD and PSA values and smaller prostate volume than did those in group 1. Prostate-specific antigen density of 0.26 ng/mL per cm 3 or higher, PSA of 7.63 ng/mL or higher, and prostate volume of 25.1 cm 3 or less were related to GS upgrade, with area-under-the-curve values of 0.765, 0.721, and 0.639, respectively. Conclusions: Magnetic resonance imaging–based PSAD could help in predicting postoperative GS upgrade in patients with low-risk prostate cancer.