Maternal obesity attenuates predelivery inflammatory reaction in C57BL/6N mice. (August 2017)

• Record Type: Journal Article
• Authors: Appel, Sarah; Schulze-Edinghausen, Merle; Kretschmer, Tobias; Storck, Sarah; Janoschek, Ruth; Bae-Gartz, Inga; Handwerk, Marion; Wohlfarth, Maria; Nüsken, Kai-Dietrich; Hucklenbruch-Rother, Eva; Heykants, Malte; Mahabir, Esther; Dötsch, Jörg
• Is Part Of: Journal of reproductive immunology. Volume 122(2017)
• Page Start: 10
• Page End: 13
• Publication Date: 2017-08
• Subjects: Inflammation -- Placenta -- Oxidative stress -- Gonadal white adipose tissue -- Maternal obesity; Reproduction -- Immunological aspects -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Reproduction -- Periodicals; Reproduction -- Immunologie -- Périodiques; Immunologie -- Périodiques; Immunology; Reproduction -- Immunological aspects; Periodicals; Electronic journals; Electronic journals; 615.766
• DOI: 10.1016/j.jri.2017.06.004
• Languages: English
• ISSNs: 0165-0378

Abstract

Abstract: Inflammation and oxidative stress are known to increase before labour. Whether gonadal white adipose tissue (gWAT) participates in this process and whether labour-related processes in placental and adipose tissue are altered in obese women is unknown. In our mouse model, lean mice display elevated placental inflammation and oxidative stress towards the end of pregnancy, accompanied by an increased expression of pro-inflammatory factors in gWAT. Obese mice also display elevated levels of pro-inflammatory factors and oxidative stress in placentas shortly before birth. However, placental infiltration with leukocytes and an increase in gWAT pro-inflammatory factor expression in obese dams are lacking.