Live Birth Derived From Oocyte Spindle Transfer to Prevent Mitochondrial Disease. Issue 9 (September 2017)

• Record Type: Journal Article
• Authors: Zhang, John; Liu, Hui; Luo, Shiyu; Lu, Zhuo; Chávez-Badiola, Alejandro; Liu, Zitao; Yang, Mingxue; Merhi, Zaher; Silber, Sherman J.; Munné, Santiago; Konstandinidis, Michalis; Wells, Dagan; Huang, Taosheng
• Is Part Of: Obstetrical & gynecological survey. Volume 72:Issue 9(2017)
• Publication Date: 2017-09
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Surgery -- Periodicals; 618
• DOI: 10.1097/01.ogx.0000524508.40309.08
• Languages: English
• ISSNs: 0029-7828

Abstract

Abstract : (Abstracted from Reprod Biomed 2017;34:361–368) It is estimated that at least 1 in 5000 people in the general population has 1 mutation in mitochondrial DNA (mtDNA), which can cause maternally inherited mitochondrial disorders. When both mutant mitochondrial and wild-type (normal) genomes coexist (heteroplasmy), the severity of symptoms is associated with the level of mtDNA mutation load or degree of heteroplasmy.