Nectrianolins A, B, and C, new metabolites produced by endophytic fungus Nectria pseudotrichia 120-1NP. Issue 43 (25th October 2017)

• Record Type: Journal Article
• Authors: Ariefta, Nanang Rudianto; Kristiana, Priska; Nurjanto, Handojo Hadi; Momma, Hiroyuki; Kwon, Eunsang; Ashitani, Tatsuya; Tawaraya, Keitaro; Murayama, Tetsuya; Koseki, Takuya; Furuno, Hiroshi; Usukhbayar, Narandulam; Kimura, Ken-ichi; Shiono, Yoshihito
• Is Part Of: Tetrahedron letters. Volume 58:Issue 43(2017)
• Page Start: 4082
• Page End: 4086
• Publication Date: 2017-10-25
• Subjects: Endophyte -- Nectria pseudotrichia -- Cytotoxicity -- Nectrianolins; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.09.032
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Chemical study of metabolites produced by fungal endophyte Nectria pseudotrichia 120-1NP. Isolation of two sesquiterpene-epoxycyclohexenone conjugates and its one sesquiterpene congener from fungal endophyte. Their structures were elucidated on the basis of spectroscopy analyses. Abstract: Two sesquiterpene-epoxycyclohexenone conjugates, nectrianolins A (1 ) and B (2 ), together with a sesquiterpene, nectrianolin C (3 ), were isolated from the brown rice culture of Nectria pseudotrichia 120-1NP, an endophytic fungus isolated from Gliricidia sepium . Their structures were determined on the basis of 1D-/2D-NMR spectroscopy and HRESIMS data analyses in combination with chemical means. Nectrianolins A–C (1 –3 ) exhibited cytotoxic activity against both HL60 and HeLa cells.