Increased expression of resistin in ectopic endometrial tissue of women with endometriosis. (6th July 2017)

• Record Type: Journal Article
• Authors: Oh, Yoon Kyung; Ha, Young Ran; Yi, Kyong Wook; Park, Hyun Tae; Shin, Jung‐Ho; Kim, Tak; Hur, Jun‐Young
• Is Part Of: American journal of reproductive immunology. Volume 78:Number 5(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-07-06
• Subjects: adipokine -- endometriosis -- inflammation -- resistin; Human reproduction -- Immunological aspects -- Periodicals; 616.69206
• DOI: 10.1111/aji.12726
• Languages: English
• ISSNs: 1046-7408

Abstract

Abstract : Problem: Inflammation is a key process in the establishment and progression of endometriosis. Resistin, an adipocytokine, has biological properties linked to immunologic functions, but its role in endometriosis is unclear. Method of study: Resistin gene expression was examined in eutopic and ectopic endometrial tissues from women with (n=25) or without (n=25) endometriosis. Resistin mRNA and protein levels were determined in endometrial tissue using quantitative real‐time reverse transcription PCR and Western blotting, following adipokine profiling arrays. Results: Resistin protein was detected in human endometrial tissues using an adipokine array test. Resistin mRNA and protein levels were significantly higher in ectopic endometrial tissue of patients with endometriosis than in normal eutopic endometrial tissue. Conclusion: Our results indicate that resistin is differentially expressed in endometrial tissues from women with endometriosis and imply a role for resistin in endometriosis‐associated pelvic inflammation. Abstract : Resistin mRNA expression is significantly higher in ectopic endometrial tissues of patients with endometriosis than in eutopic endometrial tissues of women without disease.