Emergence of colistin-resistant Escherichia coli clinical isolates harboring mcr-1 in Vietnam. (October 2017)

• Record Type: Journal Article
• Authors: Tada, Tatsuya; Nhung, Pham Hong; Shimada, Kayo; Tsuchiya, Mitsuhiro; Phuong, Doan Mai; Anh, Nguyen Quoc; Ohmagari, Norio; Kirikae, Teruo
• Is Part Of: International journal of infectious diseases. Volume 63(2017:Oct.)
• Page Start: 72
• Page End: 73
• Publication Date: 2017-10
• Subjects: Colistin resistance -- mcr-1 -- Escherichia coli -- Vietnam; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2017.07.003
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: Two colistin-resistant Escherichia coli isolates harboring mcr-1 were isolated in a medical setting in Vietnam. The 2 isolates belonged to ST410 and ST457, respectively, and several reports have described the isolation of E. coli ST410 and ST457 from food and pet animals in various countries around the world. The 2 isolates possessed a single copy of an insertion element IS Apl1 upstream of mcr-1, which also can contribute to the insertion of mcr-1 from bacterial plasmids into chromosomes. To our knowledge, this is the first report of hospital-acquired E. coli isolates harboring mcr-1 in a medical setting in Vietnam. Abstract: The mcr-1 was first detected on a plasmid in colistin-resistant Escherichia coli from livestock and patients in China. We described here the emergence of colistin-resistant E. coli clinical isolates harboring mcr-1 on the chromosomes in Vietnam. To our knowledge, this is the first report of hospital-acquired E. coli isolates harboring mcr-1 in a medical setting in Vietnam.