A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study. (October 2017)

• Record Type: Journal Article
• Authors: Risslegger, B.; Zoran, T.; Lackner, M.; Aigner, M.; Sánchez-Reus, F.; Rezusta, A.; Chowdhary, A.; Taj-Aldeen, S.J.; Arendrup, M.C.; Oliveri, S.; Kontoyiannis, D.P.; Alastruey-Izquierdo, A.; Lagrou, K.; Lo Cascio, G.; Meis, J.F.; Buzina, W.; Farina, C.; Drogari-Apiranthitou, M.; Grancini, A.; Tortorano, A.M.; Willinger, B.; Hamprecht, A.; Johnson, E.; Klingspor, L.; Arsic-Arsenijevic, V.; Cornely, O.A.; Meletiadis, J.; Prammer, W.; Tullio, V.; Vehreschild, J.-J.; Trovato, L.; Lewis, R.E.; Segal, E.; Rath, P.-M.; Hamal, P.; Rodriguez-Iglesias, M.; Roilides, E.; Arikan-Akdagli, S.; Chakrabarti, A.; Colombo, A.L.; Fernández, M.S.; Martin-Gomez, M.T.; Badali, H.; Petrikkos, G.; Klimko, N.; Heimann, S.M.; Houbraken, J.; Uzun, O.; Edlinger, M.; Fuente, S. de la; Lass-Flörl, C.;
• Is Part Of: Clinical microbiology and infection. Volume 23:Number 10(2017)
• Page Start: 776.e1
• Page End: 776.e5
• Publication Date: 2017-10
• Subjects: Amphotericin B -- Aspergillosis -- Aspergillus terreus -- Crytic species -- In vitrosusceptibility; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2017.04.012
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: Objectives: A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B susceptibility of Aspergillus terreus species complex infections. Methods: A total of 370 cases from 21 countries were evaluated. Results: The overall prevalence of A. terreus species complex among the investigated patients with mould-positive cultures was 5.2% (370/7116). Amphotericin B MICs ranged from 0.125 to 32 mg/L, (median 8 mg/L). Conclusions: Aspergillus terreus species complex infections cause a wide spectrum of aspergillosis and the majority of cryptic species display high amphotericin B MICs.