The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis. (October 2017)

• Record Type: Journal Article
• Authors: Sosnowska, Bożena; Mazidi, Mohsen; Penson, Peter; Gluba-Brzózka, Anna; Rysz, Jacek; Banach, Maciej
• Is Part Of: Atherosclerosis. Volume 265(2017)
• Page Start: 275
• Page End: 282
• Publication Date: 2017-10
• Subjects: Atherosclerosis -- CVD -- Sirtuin -- SIRT1 -- SIRT3 -- SIRT6 -- Oxidative stress -- Lipid metabolism; ABC Adenosine triphosphate binding cassette -- ABCG ABC sub-family G member -- ADP Adenosine diphosphate -- AMPK Adenosine monophosphate-activated protein kinase -- eNOS Endothelial nitric oxide synthase -- FOXO Forkhead transcription factor subclass O -- HDL-C High-density lipoprotein cholesterol -- HIF1A Hypoxia-inducible factor 1A -- HUVEC Human umbilical vein endothelial cells -- LDL-C Low-density lipoprotein cholesterol -- LDLR Low-density lipoprotein receptor -- LOX-1 Lectin-like oxidized low-density lipoprotein receptor-1 -- LXR Liver X receptor -- MnSOD Manganese-dependent superoxide dismutase -- NAD Nicotinamide adenine dinucleotide -- NADPH Nicotinamide adenine dinucleotide phosphate (reduced form) -- N-CoR Nuclear receptor co-repressor -- NF-κB Nuclear factor κB -- NFATc2 Nuclear factor of activated T cells 2 -- ox-LDL Oxidized low-density lipoprotein -- p53 Tumor protein 53 -- PCSK9 Proprotein convertase subtilisin/kexin 9 -- PGC-1α Peroxisome proliferator-activated receptor-γ co-activator-1α -- ROS Reactive oxygen species -- SIRT Silent mating-type information regulation -- SOD2 Superoxide dismutase 2 -- SR-B1 Scavenger receptor class B type I -- STAT3 Signal transducer and activator of transcription-3 -- VCAM-1 Vascular cell adhesion molecule-1; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2017.08.027
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: The sirtuins, silent mating-type information regulation 2 (SIRTs), are a family of nicotinamide adenine dinucleotide (NAD + )-dependent histone deacetylases with important roles in regulating energy metabolism and senescence. Activation of SIRTs appears to have beneficial effects on lipid metabolism and antioxidants, prompting investigation of the roles of these proteins in atherogenesis. Although clinical data are currently limited, the availability and safety of SIRT activators such as metformin and resveratrol provide an excellent opportunity to conduct research to better understand the role of SIRTs in human atherosclerosis. Encouraging observations from preclinical studies necessitate rigorous large, prospective, randomized clinical trials to determine the roles of SIRT activators on the progression of atherosclerosis and ultimately on cardiac outcomes, such as myocardial infarction and mortality. Highlights: The sirtuins (SIRTs) are a family of nicotinamide adenine dinucleotide (NAD + )-dependent histone deacetylases. SIRTS have important roles in regulating energy metabolism and senescence. Activation of SIRTs appears to have beneficial effects on lipid metabolism and antioxidants. The availability and safety of SIRT activators provide opportunity to better understand the role of SIRTs in atherosclerosis.