Early presentation of osteonecrosis in acute lymphoblastic leukemia: Two children from the Nordic and Baltic cohort. Issue 11 (18th May 2017)

• Record Type: Journal Article
• Authors: Mogensen, Signe Sloth; Harila‐Saari, Arja; Frandsen, Thomas Leth; Lähteenmäki, Päivi; Castor, Anders; Kohonen, Ia; Schmiegelow, Kjeld; Mäkitie, Outi
• Is Part Of: Pediatric blood & cancer. Volume 64:Issue 11(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-05-18
• Subjects: acute lymphoblastic leukemia -- children -- early manifestation -- osteonecrosis -- skeletal complication; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26624
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Osteonecrosis (ON) is usually considered treatment related in patients with acute lymphoblastic leukemia (ALL). We report two patients with presentation of ON at the time of ALL diagnosis. Both were females and diagnosed with ALL at age 8 and 14 years. In the latter, some symptoms and radiologically verified ON in both knees were still present after the end of ALL therapy. No pediatric patients have previously been reported with ON presenting before initiation of ALL therapy.