Clinical case series of pediatric hepatic angiosarcoma. Issue 11 (18th May 2017)

• Record Type: Journal Article
• Authors: Grassia, Kalee L.; Peterman, Caitlin M.; Iacobas, Ionela; Margolin, Judith F.; Bien, Ewa; Padhye, Bhavna; Meyers, Rebecka L.; Adams, Denise M.
• Is Part Of: Pediatric blood & cancer. Volume 64:Issue 11(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-05-18
• Subjects: hemangioendothelioma -- hepatic angiosarcoma -- hepatic hemangioma -- infantile hemangioma; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26627
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: Hepatic angiosarcoma is a rare, aggressive, malignant neoplasm with fewer than 50 cases reported in children. Prognosis is poor, with a minority surviving beyond 2 years after diagnosis. We report eight cases of pediatric hepatic angiosarcoma, diagnosed at a mean age of 3 years. Seven were initially diagnosed with an infantile hepatic hemangioendothelioma (IHHE) or hemangioma and the eighth with a "vascular tumor." Two patients, who received liver transplant, survived. We suggest hepatic hemangiomas can rarely transform into angiosarcomas and a subset of IHHEs (Type II) are actually a low‐grade form of angiosarcoma rather than a benign lesion.