Failure of MIBG scan to detect metastases in SDHB‐mutated pediatric metastatic pheochromocytoma. Issue 11 (14th April 2017)

• Record Type: Journal Article
• Authors: Sait, Sameer; Pandit‐Taskar, Neeta; Modak, Shakeel
• Is Part Of: Pediatric blood & cancer. Volume 64:Issue 11(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-04-14
• Subjects: imaging -- metastatic pheochromocytoma -- solid tumor; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26549
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract: 123 I‐meta‐iodo benzyl guanidine (MIBG) scans are considered the gold standard imaging in neuroblastoma; however, flouro deoxy glucose positron emission tomography (FDG‐PET) scans have increased sensitivity in adults with pheochromocytoma/paraganglioma. We describe a pediatric patient initially considered to have localized neuroblastoma based on anatomical imaging and 123 I‐MIBG scan, but subsequent investigations revealed germline succinate dehydrogenase complex iron sulfur subunit B (SDHB) mutation–associated pheochromocytoma with multiple FDG‐avid skeletal metastases. We then compared 123 I‐MIBG and FDG‐PET scans in children with metastatic pheochromocytoma/paraganglioma. FDG‐PET was superior to 123 I‐MIBG scan for the detection of skeletal metastases (median number of skeletal lesions detected 10 [range 1–30] vs. 2 [range 1–26], respectively; P = 0.005 by t‐test). FDG‐PET should be considered the functional scan of choice in children with pheochromocytoma/paraganglioma.