Pyrazolo[5, 1‐c][1, 2, 4]triazoles: Antimicrobial, Antitumor Activities, and Computational Docking Studies. (10th May 2017)

• Record Type: Journal Article
• Authors: Farghaly, Thoraya A.; Abdallah, Magda A.; Mahmoud, Huda K.; El‐Metwaly, Nashwa; Elaasser, Mahmoud
• Is Part Of: Journal of heterocyclic chemistry. Volume 54:Number 5(2017:Sep.)
• Page Start: 2859
• Page End: 2866
• Publication Date: 2017-05-10
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2892
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : A new series of pyrazolotriazoles7a–l, 11, and15a–c derived from the reaction of 3‐amino‐4‐(arylhydrazono)‐4, 5‐dihydropyrazol‐5‐one3a, b with various types of hydrazonoyl chlorides4, 10, 12, and13 was being synthesized in existence of triethylamine. The spectral data were assured the postulated structures for all compounds. All 7‐arylazopyrazolo[5, 1‐ c ][1, 2, 4]triazole derivatives7a–l, 11, and15a–c have been evaluated for their antimicrobial and antitumor activities, and the results show that some derivatives have good to mild utility as antitumor and antibacterial operators. Moreover, the computational studies using AutoDock tools 4.2 are confirming the results in biological activity. Abstract :