Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery. Issue 10 (10th July 2017)

• Record Type: Journal Article
• Authors: Broglie, Martina A.; Stoeckli, Sandro J.; Sauter, Rafael; Pasche, Philippe; Reinhard, Antoine; de Leval, Laurence; Huber, Gerhard F.; Pezier, Thomas F.; Soltermann, Alex; Giger, Roland; Arnold, Andreas; Dettmer, Matthias; Arnoux, Andre; Müller, Martin; Spreitzer, Stefan; Lang, Florian; Lutchmaya, Mathieu; Stauffer, Edouard; Espeli, Vittoria; Martucci, Francesco; Bongiovanni, Massimo; Foerbs, Diana; Jochum, Wolfram
• Is Part Of: Head & neck. Volume 39:Issue 10(2017)
• Page Start: 2004
• Page End: 2015
• Publication Date: 2017-07-10
• Subjects: human papillomavirus -- oropharynx -- squamous cell cancer -- surgery -- survival; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24865
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC. Methods: Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk‐of‐death categories according to a study from 2010 as stratification factors. Results: The 5‐year overall survival (OS) and disease‐specific survival (DSS) rates after surgery alone were higher in HPV‐associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03). Patients in the low‐risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate‐risk group (OS 63%; DSS 83%), and high‐risk group (OS 61%; DSS 75%). Conclusion: Nonsmokers with HPV‐positive oropharyngeal SCC have a better prognosis than smokers with HPV‐positive oropharyngeal SCC and also than patients with HPV‐negative tumors when treated by surgery alone.