EGFR gene mutation in gastrointestinal stromal tumours. Issue 4 (24th July 2017)

• Record Type: Journal Article
• Authors: Shi, Shan‐Shan; Wu, Nan; He, Yan; Wei, Xue; Xia, Qiu‐Yuan; Wang, Xuan; Ye, Sheng‐Bin; Li, Rui; Rao, Qiu; Zhou, Xiao‐Jun
• Is Part Of: Histopathology. Volume 71:Issue 4(2018)
• Page Start: 553
• Page End: 561
• Publication Date: 2017-07-24
• Subjects: EGFR -- GIST -- immunohistochemistry -- sequence -- wild‐type GIST; Histology, Pathological -- Periodicals; 611.018
• DOI: 10.1111/his.13251
• Languages: English
• ISSNs: 0309-0167

Abstract

Abstract : Aims: The aim of this study was to evaluate the mutation status of epidermal growth factor receptor ( EGFR ) in gastrointestinal stromal tumours (GISTs) and its association with various clinicopathological variables, as well as to discuss further the effects of EGFR mutations on tumour formation and progression. Methods and results: A well‐characterized cohort of 323 GISTs, obtained between 2010 and 2015 from the surgical pathology files of at the Department of Pathology of the Nanjing Jinling Hospital, was screened for mutations in exons 19 and 21 of the EGFR gene. Patient clinical data and clinicopathological features were collected if available in the medical records. Among the 323 primary GISTs, we identified three cases (0.93%) of EGFR mutations; these mutations never occurred together with KIT, PDGFRα, KRAS or BRAF mutations. In two cases, tumour cells exhibited spindle cell morphology and, in one case, epithelioid cell morphology. Additionally, the morphology and immunophenotype of these three cases did not show significant differences compared to common GISTs. The clinical results in summary were that two cases of EGFR ‐mutated GISTs occurred in females and in the stomach. The mean age of EGFR ‐mutated cases was 54.33 years, and the follow‐up data indicated that these tumours were low risk and exhibited low recurrence. Conclusions: We first established that GISTs carrying EGFR mutation are relatively benign tumours. Although EGFR mutations were rarely present in GIST, EGFR seems to play a significant role in the development and progression of GIST.