Increased frequencies of circulating and tumor-resident Vδ1+ T cells in patients with diffuse large B-cell lymphoma. Issue 1 (2nd January 2018)

• Record Type: Journal Article
• Authors: Reboursiere, Emilie; Gac, Anne-Claire; Garnier, Anthony; Salaun, Véronique; Reman, Oumedaly; Pham, Anne-Dominique; Cabrera, Quentin; Khoy, Kathy; Vilque, Jean-Pierre; Fruchart, Christophe; Chantepie, Sylvain; Johnson-Ansah, Hyacinthe; Macro, Margaret; Cheze, Stéphane; Benabed, Khaled; Mear, Jean-Baptiste; Troussard, Xavier; Damaj, Gandhi; Le Mauff, Brigitte; Toutirais, Olivier
• Is Part Of: Leukemia & lymphoma. Volume 59:Issue 1(2018)
• Page Start: 187
• Page End: 195
• Publication Date: 2018-01-02
• Subjects: Gamma-delta T cells -- diffuse large B-cell lymphoma -- cancer immunosurveillance -- immunotherapy; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2017.1321751
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Gamma-delta (γδ) T cells contribute to the innate immune response against cancer. In samples of 20 patients upon DLBCL diagnosis, we found that Vδ1 + T cells were the major γδ T cell subset in tumors and PBMCs of patients, while Vδ2 T cells were preponderant in PBMCs of healthy subjects. Interestingly, the germinal center (GC) subtype was associated with an increase in Vδ1 + T cells in tumors, whereas the non-GC subtype was associated with a lower frequency of γδ T cells. While circulating Vδ1 + T cells of patients or HSs mostly exhibited a naïve phenotype, the majority of tumor Vδ1 + T cells showed a central memory phenotype. Resident or circulating γδ T cells from patients were not functionally impaired since they produced high levels of IFN-γ. Collectively, our findings are in favor of γδ T cell activation in tumors and open new perspectives for their modulation in DLBCL immunotherapy.