High proportion of modern genotypes of M. tuberculosis and their affinity with drug resistance in northern region of India. (September 2017)

• Record Type: Journal Article
• Authors: Dhatwalia, Sunil Kumar; Yadav, Rakesh; Behera, Digambar; Kaur, Harsimran; Kumar, Manoj; Sethi, Sunil
• Is Part Of: Journal of global antimicrobial resistance. Volume 10(2017)
• Page Start: 84
• Page End: 87
• Publication Date: 2017-09
• Subjects: M. tuberculosis -- TbD1 deletion -- Drug resistance -- Ancient and modern genotypes; Drug resistance -- Periodicals; Drug resistance -- Periodicals; Drug resistance; Periodicals; 616.9041
• DOI: 10.1016/j.jgar.2017.04.010
• Languages: English
• ISSNs: 2213-7165

Abstract

Highlights: Drug resistance pattern for first line antituberculosis drugs was determined and their association with TbD1 deletion was investigated. Overall proportion of modern and ancient genotypes was also determined by meta-analysis from various studies conducted in India. Overall modern genotypes predominate in northern region of India/India; they shows higher affinity for drug resistance. Abstract: Objectives: Comparative genomics on the basis of TbD1 deletion has differentiated the members of Mycobacterium tuberculosis complex (MTC) in two major genogroups. They exhibit differential distribution and virulence potential. The present study was carried out to see the proportion of these genogroups and their association with drug resistance. Methods: The drug resistance pattern of 205 culture positive cases of M. tuberculosis and their relation with TbD1 deletion was analysed from the tertiary care centre. Overall proportion of genotypes (TbD1− and Tbd1+) and their association with drug resistance was also observed from the various studies from India. Results: Our study reports that 85.4% of the isolates of M. tuberculosis were modern genotypes (TbD1−) and rest of 14.6% were ancient genotypes (TbD1+). 37 cases were of multiple drug resistant-TB (MDR-TB), 35 of them belongs to modern genogrop and rest of (2) were in ancient genogroup (p = 0.12). Overall pooled estimate of proportion of modern genotype is 75.5% (CI 95%, 73.03–77.87) and 24.55% (CI 95%, 22.13–26.97) for ancient genotypes from the studies carried out in India. Modern genotypes were more rarely drug sensitive phenotypes with a relative risk (RR) of 0.89 (CI 95%, 0.74–1.07) while MDR cases were more in this group with an odds ratio (OR) of 2.27 (CI 95%, 0–1.07). Conclusions: This study demonstrates a higher proportion of modern genotypes in our region/India; which are more likely to be associated with drug resistance. Future, epidemiological/in vitro studies are required to ascertain the relationship between genotypes and their virulence potential.