Overexpression of AQP3 and AQP10 in the skin exacerbates psoriasiform acanthosis. Issue 10 (21st April 2017)

• Record Type: Journal Article
• Authors: Soler, David C.; Young, Andrew E.; Griffith, Alexis D.; Fu, Ping fu; Cooper, Kevin D.; McCormick, Thomas S.; Popkin, Daniel L.
• Is Part Of: Experimental dermatology. Volume 26:Issue 10(2017)
• Page Start: 949
• Page End: 951
• Publication Date: 2017-04-21
• Subjects: aquaporin‐3 -- aquaporin‐10 -- dermatitis -- filaggrin -- imiquimod; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/exd.13307
• Languages: English
• ISSNs: 0906-6705

Abstract

Abstract: We previously observed that aquaporin‐3 and aquaporin‐10 are upregulated in the epidermis of hand dermatitis patients (Med. Hypotheses, 84, 2015, 498). To address the functional relevance of this upregulation, we overexpressed AQP3/AQP10 in mice using the human K1 promoter. Combining imiquimod with detergent‐containing water challenge, a common trigger in hand and other dermatitis, resulted in an increase in acanthosis in mice overexpressing AQP3 or AQP3 and AQP10. Aquaporin overexpression also drove a trend towards greater weight loss in these animals. These data support a role for cutaneous aquaporins in the pathogenesis of dermatitis and as a potential target in their treatment.