Long term impact of the endocrine disruptor tributyltin on male fertility following a single acute exposure. Issue 10 (14th July 2017)

• Record Type: Journal Article
• Authors: Mitra, Sumonto; Srivastava, Ankit; Khandelwal, Shashi
• Is Part Of: Environmental toxicology. Volume 32:Issue 10(2017)
• Page Start: 2295
• Page End: 2304
• Publication Date: 2017-07-14
• Subjects: blood‐testis barrier -- endocrine disruptor -- male reproductive toxicity -- steroidogenesis -- tributyltin; Water quality bioassay -- Periodicals; Water -- Pollution -- Toxicology -- Periodicals; Microbiological assay -- Periodicals; Toxicity testing -- Periodicals; Environmental toxicology -- Periodicals; Environmental Pollution -- Periodicals; Environmental Pollutants -- Periodicals; Environmental Monitoring -- Periodicals; Écotoxicologie -- Périodiques; Pollution -- Périodiques; 615.902
• DOI: 10.1002/tox.22446
• Languages: English
• ISSNs: 1520-4081

Abstract

Abstract: Declining rate of human fertility is a growing concern, where lifestyle and environmental factors play an important role. We recently demonstrated that tributyltin (TBT), an omnipresent endocrine disruptor, affects testicular cells in vitro. In this study, male Wistar rats were gavaged a single dose of 10, 20, and 30 mg/kg TBT‐chloride (TBTC) (to mimic accidental exposure in vivo) and sacrificed on day 3 and day 7, respectively. TBT bioavailability was evaluated by estimating total tin content, and essential metal levels were analyzed along with redox molecules (ROS and GSH/GSSG) to understand the effect on physiological conditions. Blood‐testicular barrier (BTB) disruption, levels of associated proteins and activity of proteolytic enzymes were evaluated to understand the effect on BTB. Histological analysis of tissue architecture and effect on protein expression of steroidogenic, stress and apoptotic markers were also evaluated. Widespread TBTC pollution can be an eventual threat to male fertility worldwide.