A Simple One‐Pot Synthesis of Fully Substituted 1H‐Pyridone[1, 2‐a]‐Fused‐1, 3‐Diazaheterocycles. (12th April 2017)

• Record Type: Journal Article
• Authors: Bayat, Mohammad; Rezaee, Monireh; Zhu, Long‐Guan
• Is Part Of: Journal of heterocyclic chemistry. Volume 54:Number 5(2017:Sep.)
• Page Start: 2748
• Page End: 2754
• Publication Date: 2017-04-12
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2877
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : An efficient procedure for the synthesis of 7‐(aryl)‐8‐nitro‐2, 3, 6, 7‐tetrahydroimidazo[1, 2‐a]pyridinones, 8‐(aryl)‐9‐nitro‐3, 4, 7, 8‐tetrahydropyridone[1, 2‐a]pyrimidines and 9‐(aryl)‐10‐nitro‐2, 3, 4, 5, 8, 9‐hexahydropyridone[1, 2‐a]diazepine via one‐pot three component reaction of diamine, nitroketene dithioacetal (1, 1‐bis(methylsulfanyl)‐2‐nitroethene), and coumarine‐3‐ carboxylic acid derivatives in EtOH under reflux conditions is reported. The advantages of this procedure are simplicity, easy purification, good yields, and catalyst‐free conditions. All products were confirmed by 1 H‐ and 13 C‐NMR, IR, MS, and X‐ray crystal structure analyses. Abstract :