Synthesis of Hydrazones from Amino Acids and their Antimicrobial and Cytotoxic Activities. Issue 9 (18th July 2017)

• Record Type: Journal Article
• Authors: Abid, Obaid‐ur‐Rahman; Khatoon, Ghamama; Arfan, Muhammad; Sajid, Imran; Langer, Peter; Rehman, Wajid; Rahim, Fazal; Yasir, Muhammad; Waqar, Muhammad; Haleem, Kashif Syed
• Is Part Of: Journal of the Chinese Chemical Society. Volume 64:Issue 9(2017:Sep.)
• Page Start: 1079
• Page End: 1087
• Publication Date: 2017-07-18
• Subjects: Hydrazones -- Cytotoxicity -- Amino acids -- Antimicrobial; Chemistry -- Periodicals; Electronic journals; 540.5
• DOI: 10.1002/jccs.201600859
• Languages: English
• ISSNs: 0009-4536

Abstract

Abstract : Hydrazones6a–6n were synthesized from different amino acids with various aldehydes under reflux in methanol/ethanol. The structures of synthesized compounds were ascertained by elemental analysis and spectroscopic techniques. A comparative study of the antimicrobial activity and cytotoxicity was carried out of the N‐protected amino acids, their esters, hydrazides, and the respective hydrazones, providing good results in cytotoxicity studies. Abstract : Hydrazones6a–6n were synthesized from different amino acids with various aldehydes under reflux in methanol/ethanol. The structures of synthesized compounds were ascertained by elemental analysis and spectroscopic techniques. A comparative study of the antimicrobial activity and cytotoxicity was carried out for N‐protected amino acids, their esters, hydrazides, and the respective hydrazones.