Importance of DOTA derivatives in bimodal imaging. Issue 9 (13th June 2017)

• Record Type: Journal Article
• Authors: Chilla, Satya Narayana Murthy; Henoumont, Céline; Elst, Luce Vander; Muller, Robert N.; Laurent, Sophie
• Is Part Of: Israel journal of chemistry. Volume 57:Issue 9(2017)
• Page Start: 800
• Page End: 808
• Publication Date: 2017-06-13
• Subjects: DOTA -- Contrast agents -- Multimodal Imaging -- MRI -- Optical Imaging -- Radionuclear; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/ijch.201700024
• Languages: English
• ISSNs: 0021-2148

Abstract

Abstract: The clinical applications of multimodal probes are numerous since a few decades. 1, 4, 7, 10‐tetraazacyclododecane‐1, 4, 7, 10‐tetraacetic acid (DOTA) has played an important role in diagnostic and therapeutic areas. The vast applications of DOTA as chelator have been explored in magnetic resonance imaging (MRI) and in radioisotope chemistry. Moreover, the possibility to functionalize the macrocycle with pendant arms has allowed to explore new functionalities as bimodal imaging agents. Different combinations are possible between the different possible imaging techniques like Magnetic Resonance Imaging, Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Optical imaging (OI). The main use of DOTA and its derivatives was for MRI as gadolinium complexes. It was then further extended to the complexation with europium or terbium for optical imaging. Although other chelates are available such as DTPA or NOTA, derivatives of DOTA were often the primary choice due to their versatility. DOTA derivatives can indeed also be complexed with radioisotopes and conjugated to peptides which leads to targeted contrast agents for PET or SPECT. Depending on the chosen imaging modality, a variety of radiometals can be complexed with DOTA, e.i. 64 Cu and 68 Ga for PET, or 111 In and 90 Y for SPECT. Conjugation of chromophores to gadolinium complexes of DOTA derivatives can also lead to bimodal agents for MRI and OI. In this review, we will provide the applications of DOTA and its derivatives in different imaging modalities and their clinical applications. Abstract :