Does the number of previous miscarriages influence the incidence of chromosomal aberrations in spontaneous pregnancy loss?. (17th December 2017)

• Record Type: Journal Article
• Authors: Goldstein, Myriam; Svirsky, Ran; Reches, Adi; Yaron, Yuval
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 30:Number 24(2017)
• Page Start: 2956
• Page End: 2960
• Publication Date: 2017-12-17
• Subjects: Recurrent miscarriage -- abortion -- karyotype -- pregnancy loss; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2016.1269317
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective: Chromosomal aberrations are a common cause for miscarriage. The purpose of this study was to evaluate factors that influence the frequency of chromosomal abnormalities in miscarriages and provide clinicians with a guideline for management of such cases. Methods: The study included 170 women who experienced pregnancy loss between the 2004 and 2014. Cytogenetic analysis of products of conception (POC) was routinely performed. Results: Successful cytogenetic analysis was achieved in 144 cases (84%). Of these, 78 cases (54%) had a chromosomal aberration. The incidence of chromosomal aberrations was not statistically significant among patients with 1, 2, 3, 4 or ≥5 previous miscarriages (33.3%, 57.4%, 48.6%, 65.2%, and 59.1%, respectively, p = 0.227). The F/M ratio was similar in normal and abnormal POC karyotypes (1.2:1 and 1.3:1, respectively, p = 0.7). Conclusion: Contrary to previous assumptions we did not find correlation between number of previous spontaneous miscarriages a women experienced and chromosomal aberration in her current miscarriage.