Association between maternal circulating 25 hydroxyvitamin D concentration and placental volume in the first trimester. (17th December 2017)

• Record Type: Journal Article
• Authors: Yayla Abide, Çiğdem; Kurek Eken, Meryem; Turan, Işıl; Özkaya, Enis; Pekin, Oya; Karateke, Ateş
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 30:Number 24(2017)
• Page Start: 2944
• Page End: 2950
• Publication Date: 2017-12-17
• Subjects: 25OH Dvit -- deficiency -- 3D ultrasonography -- placenta -- placental mean gray value -- VOCAL analysis; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2016.1269315
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objectives: We aimed to assess placental volume and placental mean gray value in vitamin D deficiency and healthy placentas in the first trimester of pregnancy using three-dimensional (3D) ultrasonography (USG) and Virtual Organ Computer-aided Analysis (VOCAL). Methods: This prospective cross sectional study comprised 274 patients, divided into two groups according to the presence or absence of vitamin D deficiency (<20 ng/ml deficient, n = 153, >20 ng/ml not deficient, n = 121) in the first trimester of pregnancy. Placental volume and placental volumetric mean gray values were evaluated. Placental volume (cm 3 ) was analyzed using the VOCAL imaging program and a 3D histogram was used to calculate the volumetric mean gray value (%). Results: Placental volume was significantly less in the vitamin D deficiency group ( p = 0.017) Volumetric mean gray value of the placenta was significantly higher in the vitamin D deficiency group ( p = 0.003). Maternal serum PAPP-A (MoM) and f-β Hcg (MoM) were significantly lower in the vitamin D deficiency group ( p = 0.008, p = 0.003, respectively). In linear regression analyses, serum vitamin D concentration was significantly associated with the plasental volume ( β = 0.16; p = 0.01). Conclusion: Placental configuration and development were associated with vitamin D even in the first trimester of pregnancy. To ensure healthy pregnancy outcomes, vitamin D screening applied in the early stages of pregnancy or even before pregnancy.