Relationships between interleukin-12B and interleukin-10 gene polymorphisms and hepatitis C in Chinese Han hemodialysis patients. (23rd January 2015)

• Record Type: Journal Article
• Authors: Zhu, Bei; Wang, Cuiyu; Zhang, Xiaoli; He, Juan; Wu, Jianqing; Yu, Rongbin; Zhao, Weihong
• Is Part Of: Renal failure. Volume 37:Number 3(2015)
• Page Start: 505
• Page End: 510
• Publication Date: 2015-01-23
• Subjects: Hepatitis C -- hemodialysis -- Interleukin-12B gene -- IL-10 gene -- polymorphisms; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2015.1006086
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: Background and Aims : Hepatitis C virus (HCV) commonly causes a chronic infection but portion of hemodialysis patients are able to resistant to HCV infection, even clear the virus naturally. Interleukin-10 (IL-10) and interleukin-12 (IL-12) are crucial regulators of the immune response to T-helper 1 (Th1) or T-helper 2 (Th2) categories and play a role in autoimmune and infectious diseases. This study was undertaken to investigate the possible association of genetic polymorphisms of 3′ untranslated region (3′UTR) of the IL-12B (−1188) and IL-10 (−592 and −819) and hepatitis C in Chinese Han hemodialysis (HD) patients. Methods : The genotyping of IL-12B 3′UTR and IL-10 −592 and −819 were performed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method. Results : Compared with the IL-12B-AA genotype, CC and combined CC/AC genotypes were associated with a significant decreased risk of HCV infection in Chinese hemodialysis patients ( p < 0.001). However, the IL-10−592 and −819 genotypes were not found significant difference both between the anti-HCV (+) and anti-HCV (−) patients ( p > 0.05) and the persistent infection and viral clearance HD patients ( p > 0.05). Conclusions : The present study indicated that the polymorphisms of IL-12B 3′UTR might contribute to the susceptibility of HCV infection in Chinese HD population.